02/02/2025

Top 200 Drugs Fast Pace Edition: Tricyclic Antidepressants

Tricyclic Antidepressants (TCAs) Overview
What are they?
Medications used to treat depression, anxiety, and certain pain conditions by affecting neurotransmitters in the brain. They are older antidepressants but still effective for some individuals.

How to recognize them?
Common examples include amitriptyline, nortriptyline, imipramine, and desipramine.

How do they work?
Increase the levels of neurotransmitters (such as serotonin and norepinephrine) in the brain by inhibiting their reuptake → Elevate mood, reduce anxiety, and help with pain management.

Easy trick to remember:
"Tricyclics Tame Thoughts" (They help manage mood and anxiety by adjusting brain chemistry).

Common uses:

  • Depression (major depressive disorder)

  • Anxiety disorders (such as panic disorder)

  • Chronic pain (e.g., neuropathic pain, fibromyalgia)

  • Insomnia (due to sedative effects)

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