Proton Pump Inhibitors Overview

✔ What are they?
Medications that reduce stomach acid production by blocking the enzyme responsible for acid secretion. They are commonly used to treat acid-related disorders.

✔ How to recognize them?
Most PPIs end in "-prazole", such as omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole.

✔ How do they work?
Inhibit the H+/K+ ATPase (proton pump) in stomach lining → Decrease acid secretion → Allow healing of ulcers and reduce acid-related symptoms.

✔ Easy trick to remember:
"Prazoles Prevent Proton Problems" (PPIs stop acid production in the stomach).

✔ Common uses:

• Gastroesophageal reflux disease (GERD) (acid reflux)

• Peptic ulcers (stomach or duodenal ulcers)

• Zollinger-Ellison syndrome (gastric acid overproduction)

• Erosive esophagitis (damage to esophagus from stomach acid)